Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-30 | Mississippi Valley State | 7 | North Dakota | 35 | Final | L | -28 |
| 2 | 2018-09-08 | Mississippi Valley State | 0 | Jacksonville State | 71 | Final | L | -71 |
| 3 | 2018-09-22 | Alcorn State | 56 | Mississippi Valley State | 20 | Final | L | -36 |
| 4 | 2018-10-06 | Mississippi Valley State (249) | 27 | Bethune-Cookman (206) | 41 | Final | L | -14 |
| 5 | 2018-10-13 | Mississippi Valley State (250) | 7 | Jackson State (196) | 23 | Final | L | -16 |
| 6 | 2018-10-20 | Arkansas-Pine Bluff (255) | 47 | Mississippi Valley State (248) | 48 | Final/2OT | W | 1 |
| 7 | 2018-10-27 | Mississippi Valley State (247) | 14 | Texas Southern (244) | 42 | Final | L | -28 |
| 8 | 2018-11-03 | Mississippi Valley State (250) | 19 | Grambling (208) | 24 | Final | L | -5 |
| 9 | 2018-11-10 | Hampton (228) | 54 | Mississippi Valley State (252) | 39 | Final | L | -15 |
| 10 | 2018-11-17 | Alabama A&M (211) | 42 | Mississippi Valley State (254) | 14 | Final | L | -28 |
| 11 | 2018-11-22 | Mississippi Valley State (254) | 24 | Alabama State (237) | 31 | Final/OT | L | -7 |