Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-31 | Utah State (93) | 31 | Michigan State (17) | 38 | Final | W | 7 |
| 2 | 2018-09-08 | Michigan State (17) | 13 | Arizona State (41) | 16 | Final | L | -3 |
| 3 | 2018-09-22 | Michigan State (17) | 35 | Indiana (69) | 21 | Final | W | 14 |
| 4 | 2018-09-29 | Central Michigan (127) | 20 | Michigan State (31) | 31 | Final | W | 11 |
| 5 | 2018-10-06 | Northwestern (78) | 29 | Michigan State (29) | 19 | Final | L | -10 |
| 6 | 2018-10-13 | Michigan State (53) | 21 | Penn State (7) | 17 | Final | W | 4 |
| 7 | 2018-10-20 | Michigan (5) | 21 | Michigan State (34) | 7 | Final | L | -14 |
| 8 | 2018-10-27 | Purdue (41) | 13 | Michigan State (42) | 23 | Final | W | 10 |
| 9 | 2018-11-03 | Michigan State (31) | 24 | Maryland (43) | 3 | Final | W | 21 |
| 10 | 2018-11-10 | Ohio State (10) | 26 | Michigan State (18) | 6 | Final | L | -20 |
| 11 | 2018-11-17 | Michigan State (25) | 6 | Nebraska (95) | 9 | Final | L | -3 |
| 12 | 2018-11-24 | Rutgers (127) | 10 | Michigan State (35) | 14 | Final | W | 4 |
| 13 | 2018-12-31 | Michigan State (34) | 6 | Oregon (39) | 7 | Final | L | -1 |