Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Michigan (27) | 17 | Notre Dame (10) | 24 | Final | L | -7 |
| 2 | 2018-09-08 | Western Michigan | 3 | Michigan | 49 | Final | W | 46 |
| 3 | 2018-09-15 | SMU (48) | 20 | Michigan (27) | 45 | Final | W | 25 |
| 4 | 2018-09-22 | Nebraska (84) | 10 | Michigan (27) | 56 | Final | W | 46 |
| 5 | 2018-09-29 | Michigan (17) | 20 | Northwestern (79) | 17 | Final | W | 3 |
| 6 | 2018-10-06 | Maryland (35) | 21 | Michigan (11) | 42 | Final | W | 21 |
| 7 | 2018-10-13 | Wisconsin (26) | 13 | Michigan (6) | 38 | Final | W | 25 |
| 8 | 2018-10-20 | Michigan (5) | 21 | Michigan State (34) | 7 | Final | W | 14 |
| 9 | 2018-11-03 | Penn State (12) | 7 | Michigan (4) | 42 | Final | W | 35 |
| 10 | 2018-11-10 | Michigan (4) | 42 | Rutgers (127) | 7 | Final | W | 35 |
| 11 | 2018-11-17 | Indiana (58) | 20 | Michigan (5) | 31 | Final | W | 11 |
| 12 | 2018-11-24 | Michigan (5) | 39 | Ohio State (9) | 62 | Final | L | -23 |
| 13 | 2018-12-29 | Florida (10) | 41 | Michigan (7) | 15 | Final | L | -26 |