Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Louisville (32) | 14 | Alabama (4) | 51 | Final | L | -37 |
| 2 | 2018-09-08 | Indiana State (247) | 7 | Louisville (32) | 31 | Final | W | 24 |
| 3 | 2018-09-15 | Western Kentucky | 17 | Louisville | 20 | Final | W | 3 |
| 4 | 2018-09-22 | Louisville (32) | 3 | Virginia (66) | 27 | Final | L | -24 |
| 5 | 2018-09-29 | Florida State (92) | 28 | Louisville (84) | 24 | Final | L | -4 |
| 6 | 2018-10-05 | Georgia Tech (90) | 66 | Louisville (99) | 31 | Final | L | -35 |
| 7 | 2018-10-13 | Louisville (112) | 20 | Boston College (55) | 38 | Final | L | -18 |
| 8 | 2018-10-27 | Wake Forest (91) | 56 | Louisville (111) | 35 | Final | L | -21 |
| 9 | 2018-11-03 | Louisville (116) | 16 | Clemson (1) | 77 | Final | L | -61 |
| 10 | 2018-11-09 | Louisville (116) | 23 | Syracuse (21) | 54 | Final | L | -31 |
| 11 | 2018-11-17 | North Carolina State (38) | 52 | Louisville (118) | 10 | Final | L | -42 |
| 12 | 2018-11-24 | Kentucky (13) | 56 | Louisville (122) | 10 | Final | L | -46 |