Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-30 | Southeastern Louisiana | 31 | Louisiana-Monroe | 34 | Final | W | 3 |
| 2 | 2018-09-08 | Louisiana-Monroe | 21 | Southern Miss | 20 | Final | W | 1 |
| 3 | 2018-09-15 | Louisiana-Monroe | 10 | Texas A&M | 48 | Final | L | -38 |
| 4 | 2018-09-22 | Troy | 35 | Louisiana-Monroe | 27 | Final | L | -8 |
| 5 | 2018-09-29 | Louisiana-Monroe (89) | 14 | Georgia State (124) | 46 | Final | L | -32 |
| 6 | 2018-10-06 | Louisiana-Monroe (110) | 21 | Ole Miss (47) | 70 | Final | L | -49 |
| 7 | 2018-10-13 | Louisiana-Monroe (116) | 45 | Coastal Carolina (64) | 20 | Final | W | 25 |
| 8 | 2018-10-20 | Texas State (147) | 14 | Louisiana-Monroe (102) | 20 | Final | W | 6 |
| 9 | 2018-11-03 | Georgia Southern (20) | 25 | Louisiana-Monroe (103) | 44 | Final | W | 19 |
| 10 | 2018-11-10 | Louisiana-Monroe (92) | 38 | South Alabama (123) | 10 | Final | W | 28 |
| 11 | 2018-11-17 | Louisiana-Monroe (92) | 17 | Arkansas State (78) | 31 | Final | L | -14 |
| 12 | 2018-11-24 | Louisiana (86) | 31 | Louisiana-Monroe (98) | 28 | Final | L | -3 |