Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Grambling (137) | 17 | Louisiana (129) | 49 | Final | W | 32 |
| 2 | 2018-09-15 | Louisiana | 10 | Mississippi State | 56 | Final | L | -46 |
| 3 | 2018-09-22 | Coastal Carolina | 30 | Louisiana | 28 | Final | L | -2 |
| 4 | 2018-09-29 | Louisiana (102) | 14 | Alabama (1) | 56 | Final | L | -42 |
| 5 | 2018-10-06 | Louisiana (108) | 42 | Texas State (141) | 27 | Final | W | 15 |
| 6 | 2018-10-13 | New Mexico State (117) | 38 | Louisiana (98) | 66 | Final | W | 28 |
| 7 | 2018-10-20 | Louisiana (90) | 17 | Appalachian State (20) | 27 | Final | L | -10 |
| 8 | 2018-10-27 | Arkansas State (75) | 43 | Louisiana (95) | 47 | Final | W | 4 |
| 9 | 2018-11-03 | Louisiana (86) | 16 | Troy (54) | 26 | Final | L | -10 |
| 10 | 2018-11-10 | Georgia State (125) | 22 | Louisiana (91) | 36 | Final | W | 14 |
| 11 | 2018-11-17 | South Alabama (128) | 38 | Louisiana (89) | 48 | Final | W | 10 |
| 12 | 2018-11-24 | Louisiana (86) | 31 | Louisiana-Monroe (98) | 28 | Final | W | 3 |
| 13 | 2018-12-01 | Louisiana (79) | 19 | Appalachian State (22) | 30 | Final | L | -11 |
| 14 | 2018-12-15 | Tulane (89) | 41 | Louisiana (83) | 24 | Final | L | -17 |