Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | South Dakota State | 0 | Iowa State | 7 | Canceled | W | 7 |
| 2 | 2018-09-08 | Iowa State (38) | 3 | Iowa (24) | 13 | Final | L | -10 |
| 3 | 2018-09-15 | Oklahoma (7) | 37 | Iowa State (38) | 27 | Final | L | -10 |
| 4 | 2018-09-22 | Akron (71) | 13 | Iowa State (38) | 26 | Final | W | 13 |
| 5 | 2018-09-29 | Iowa State (67) | 14 | TCU (66) | 17 | Final | L | -3 |
| 6 | 2018-10-06 | Iowa State (75) | 48 | Oklahoma State (26) | 42 | Final | W | 6 |
| 7 | 2018-10-13 | West Virginia (11) | 14 | Iowa State (62) | 30 | Final | W | 16 |
| 8 | 2018-10-27 | Texas Tech (28) | 31 | Iowa State (48) | 40 | Final | W | 9 |
| 9 | 2018-11-03 | Iowa State (32) | 27 | Kansas (105) | 3 | Final | W | 24 |
| 10 | 2018-11-10 | Baylor (64) | 14 | Iowa State (31) | 28 | Final | W | 14 |
| 11 | 2018-11-17 | Iowa State (28) | 10 | Texas (27) | 24 | Final | L | -14 |
| 12 | 2018-11-24 | Kansas State (79) | 38 | Iowa State (36) | 42 | Final | W | 4 |
| 13 | 2018-12-01 | Drake (185) | 24 | Iowa State (33) | 27 | Final | W | 3 |
| 14 | 2018-12-28 | Iowa State (35) | 26 | Washington State (17) | 28 | Final | L | -2 |