Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Northern Illinois | 7 | Iowa | 33 | Final | W | 26 |
| 2 | 2018-09-08 | Iowa State (38) | 3 | Iowa (24) | 13 | Final | W | 10 |
| 3 | 2018-09-15 | Northern Iowa (132) | 14 | Iowa (24) | 38 | Final | W | 24 |
| 4 | 2018-09-22 | Wisconsin (6) | 28 | Iowa (24) | 17 | Final | L | -11 |
| 5 | 2018-10-06 | Iowa (53) | 48 | Minnesota (40) | 31 | Final | W | 17 |
| 6 | 2018-10-13 | Iowa (25) | 42 | Indiana (42) | 16 | Final | W | 26 |
| 7 | 2018-10-20 | Maryland (33) | 0 | Iowa (16) | 23 | Final | W | 23 |
| 8 | 2018-10-27 | Iowa (14) | 24 | Penn State (16) | 30 | Final | L | -6 |
| 9 | 2018-11-03 | Iowa (15) | 36 | Purdue (47) | 38 | Final | L | -2 |
| 10 | 2018-11-10 | Northwestern (40) | 14 | Iowa (29) | 10 | Final | L | -4 |
| 11 | 2018-11-17 | Iowa (36) | 63 | Illinois (103) | 0 | Final | W | 63 |
| 12 | 2018-11-23 | Nebraska (80) | 28 | Iowa (28) | 31 | Final | W | 3 |
| 13 | 2019-01-01 | Mississippi State (14) | 22 | Iowa (30) | 27 | Final | W | 5 |