Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Indiana | 38 | Florida International | 28 | Final | W | 10 |
| 2 | 2018-09-08 | Virginia (66) | 16 | Indiana (69) | 20 | Final | W | 4 |
| 3 | 2018-09-15 | Ball State (147) | 10 | Indiana (69) | 38 | Final | W | 28 |
| 4 | 2018-09-22 | Michigan State (17) | 35 | Indiana (69) | 21 | Final | L | -14 |
| 5 | 2018-09-29 | Indiana (28) | 24 | Rutgers (112) | 17 | Final | W | 7 |
| 6 | 2018-10-06 | Indiana (28) | 26 | Ohio State (4) | 49 | Final | L | -23 |
| 7 | 2018-10-13 | Iowa (25) | 42 | Indiana (42) | 16 | Final | L | -26 |
| 8 | 2018-10-20 | Penn State (17) | 33 | Indiana (53) | 28 | Final | L | -5 |
| 9 | 2018-10-26 | Indiana (59) | 31 | Minnesota (73) | 38 | Final | L | -7 |
| 10 | 2018-11-10 | Maryland (53) | 32 | Indiana (70) | 34 | Final | W | 2 |
| 11 | 2018-11-17 | Indiana (58) | 20 | Michigan (5) | 31 | Final | L | -11 |
| 12 | 2018-11-24 | Purdue (48) | 28 | Indiana (60) | 21 | Final | L | -7 |