Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Kent State (136) | 24 | Illinois (121) | 31 | Final | W | 7 |
| 2 | 2018-09-08 | Western Illinois | 14 | Illinois | 34 | Final | W | 20 |
| 3 | 2018-09-15 | South Florida | 25 | Illinois | 19 | Final | L | -6 |
| 4 | 2018-09-21 | Penn State (8) | 63 | Illinois (121) | 24 | Final | L | -39 |
| 5 | 2018-10-06 | Illinois (80) | 38 | Rutgers (117) | 17 | Final | W | 21 |
| 6 | 2018-10-13 | Purdue (81) | 46 | Illinois (74) | 7 | Final | L | -39 |
| 7 | 2018-10-20 | Illinois (96) | 20 | Wisconsin (41) | 49 | Final | L | -29 |
| 8 | 2018-10-27 | Illinois (100) | 33 | Maryland (53) | 63 | Final | L | -30 |
| 9 | 2018-11-03 | Minnesota (62) | 31 | Illinois (107) | 55 | Final | W | 24 |
| 10 | 2018-11-10 | Illinois (99) | 35 | Nebraska (103) | 54 | Final | L | -19 |
| 11 | 2018-11-17 | Iowa (36) | 63 | Illinois (103) | 0 | Final | L | -63 |
| 12 | 2018-11-24 | Illinois (106) | 16 | Northwestern (31) | 24 | Final | L | -8 |