Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Houston (46) | 45 | Rice (153) | 27 | Final | W | 18 |
| 2 | 2018-09-08 | Arizona (57) | 18 | Houston (46) | 45 | Final | W | 27 |
| 3 | 2018-09-15 | Houston (46) | 49 | Texas Tech (63) | 63 | Final | L | -14 |
| 4 | 2018-09-22 | Texas Southern (243) | 14 | Houston (46) | 70 | Final | W | 56 |
| 5 | 2018-10-04 | Tulsa (115) | 26 | Houston (56) | 41 | Final | W | 15 |
| 6 | 2018-10-13 | Houston (45) | 42 | East Carolina (111) | 20 | Final | W | 22 |
| 7 | 2018-10-20 | Houston (46) | 49 | Navy (111) | 36 | Final | W | 13 |
| 8 | 2018-10-27 | South Florida (32) | 36 | Houston (44) | 57 | Final | W | 21 |
| 9 | 2018-11-03 | Houston (27) | 31 | SMU (94) | 45 | Final | L | -14 |
| 10 | 2018-11-10 | Temple (59) | 59 | Houston (50) | 49 | Final | L | -10 |
| 11 | 2018-11-15 | Tulane (82) | 17 | Houston (56) | 48 | Final | W | 31 |
| 12 | 2018-11-23 | Houston (53) | 31 | Memphis (73) | 52 | Final | L | -21 |
| 13 | 2018-12-22 | Houston (64) | 14 | Army (31) | 70 | Final | L | -56 |