Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Eastern Illinois | 20 | Arkansas | 55 | Final | L | -35 |
| 2 | 2018-09-08 | Eastern Illinois | 10 | Illinois State | 48 | Final | L | -38 |
| 3 | 2018-09-15 | Indiana State | 55 | Eastern Illinois | 41 | Final | L | -14 |
| 4 | 2018-09-22 | Tennessee State | 41 | Eastern Illinois | 40 | Final | L | -1 |
| 5 | 2018-09-29 | Eastern Illinois (232) | 52 | Tennessee Tech (241) | 38 | Final | W | 14 |
| 6 | 2018-10-06 | Murray State (223) | 48 | Eastern Illinois (226) | 41 | Final | L | -7 |
| 7 | 2018-10-13 | Eastern Illinois (238) | 22 | Jacksonville State (144) | 49 | Final | L | -27 |
| 8 | 2018-10-20 | Tennessee-Martin (209) | 21 | Eastern Illinois (238) | 24 | Final/OT | W | 3 |
| 9 | 2018-10-27 | Eastern Illinois (227) | 23 | Eastern Kentucky (183) | 31 | Final | L | -8 |
| 10 | 2018-11-10 | Austin Peay (202) | 21 | Eastern Illinois (231) | 52 | Final | W | 31 |
| 11 | 2018-11-17 | Eastern Illinois (221) | 32 | Southeast Missouri State (155) | 38 | Final | L | -6 |