Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Murray State (251) | 17 | East Tennessee State (170) | 45 | Final | W | 28 |
| 2 | 2025-09-06 | East Tennessee State (170) | 0 | Tennessee (9) | 0 | Scheduled – 3:30 PM | – | – |
| 3 | 2025-09-13 | East Tennessee State (170) | 0 | West Georgia (221) | 0 | Scheduled – 6:00 PM | – | – |
| 4 | 2025-09-20 | Elon (183) | 0 | East Tennessee State (170) | 0 | Scheduled – 5:30 PM | – | – |
| 5 | 2025-09-27 | Mercer (135) | 0 | East Tennessee State (170) | 0 | Scheduled – 5:30 PM | – | – |
| 6 | 2025-10-04 | East Tennessee State (170) | 0 | Furman (241) | 0 | Scheduled – 2:00 PM | – | – |
| 7 | 2025-10-11 | Virginia Military (256) | 0 | East Tennessee State (170) | 0 | Scheduled – 3:30 PM | – | – |
| 8 | 2025-10-18 | East Tennessee State (170) | 0 | Chattanooga (172) | 0 | Scheduled – 1:30 PM | – | – |
| 9 | 2025-10-25 | Wofford (204) | 0 | East Tennessee State (170) | 0 | Scheduled – 3:30 PM | – | – |
| 10 | 2025-11-08 | East Tennessee State (170) | 0 | Samford (198) | 0 | Scheduled – 2:30 PM | – | – |
| 11 | 2025-11-15 | East Tennessee State (170) | 0 | Western Carolina (175) | 0 | Scheduled – 12:00 PM | – | – |
| 12 | 2025-11-22 | The Citadel (216) | 0 | East Tennessee State (170) | 0 | Scheduled – 1:00 PM | – | – |