Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | North Carolina A&T | 0 | East Carolina | 0 | Postponed | – | – |
| 2 | 2018-09-02 | North Carolina A&T | 28 | East Carolina | 23 | Final | L | -5 |
| 3 | 2018-09-08 | North Carolina (101) | 19 | East Carolina (128) | 41 | Final | W | 22 |
| 4 | 2018-09-15 | East Carolina (128) | 0 | Virginia Tech (20) | 0 | Canceled | – | – |
| 5 | 2018-09-22 | East Carolina | 13 | South Florida | 20 | Final | L | -7 |
| 6 | 2018-09-29 | Old Dominion (107) | 35 | East Carolina (105) | 37 | Final | W | 2 |
| 7 | 2018-10-06 | East Carolina (92) | 6 | Temple (88) | 49 | Final | L | -43 |
| 8 | 2018-10-13 | Houston (45) | 42 | East Carolina (111) | 20 | Final | L | -22 |
| 9 | 2018-10-20 | Central Florida (13) | 37 | East Carolina (117) | 10 | Final | L | -27 |
| 10 | 2018-11-03 | Memphis (92) | 59 | East Carolina (114) | 41 | Final | L | -18 |
| 11 | 2018-11-10 | East Carolina (121) | 18 | Tulane (85) | 24 | Final | L | -6 |
| 12 | 2018-11-17 | Connecticut (151) | 21 | East Carolina (121) | 55 | Final | W | 34 |
| 13 | 2018-11-23 | East Carolina (118) | 6 | Cincinnati (21) | 56 | Final | L | -50 |
| 14 | 2018-12-01 | East Carolina (120) | 3 | North Carolina State (31) | 58 | Final | L | -55 |