Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-25 | Duquesne | 15 | Massachusetts | 63 | Final | L | -48 |
| 2 | 2018-09-01 | Lock Haven | 0 | Duquesne | 45 | Final | W | 45 |
| 3 | 2018-09-08 | Valparaiso (208) | 21 | Duquesne (182) | 23 | Final | W | 2 |
| 4 | 2018-09-15 | Dayton (215) | 26 | Duquesne (182) | 31 | Final | W | 5 |
| 5 | 2018-09-22 | Duquesne | 21 | Hawaii | 42 | Final | L | -21 |
| 6 | 2018-10-06 | Bryant (196) | 21 | Duquesne (183) | 20 | Final | L | -1 |
| 7 | 2018-10-13 | Robert Morris (251) | 24 | Duquesne (195) | 48 | Final | W | 24 |
| 8 | 2018-11-03 | Duquesne (187) | 47 | Wagner (242) | 30 | Final | W | 17 |
| 9 | 2018-11-10 | Sacred Heart (179) | 24 | Duquesne (188) | 28 | Final | W | 4 |
| 10 | 2018-11-17 | Duquesne (176) | 38 | Central Connecticut State (199) | 31 | Final | W | 7 |
| 11 | 2018-11-24 | Duquesne (167) | 31 | Towson (136) | 10 | Final | W | 21 |
| 12 | 2018-12-01 | Duquesne (157) | 6 | South Dakota State (113) | 51 | Final | L | -45 |