Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-31 | Army (40) | 14 | Duke (61) | 34 | Final | W | 20 |
| 2 | 2018-09-08 | Duke (61) | 21 | Northwestern (18) | 7 | Final | W | 14 |
| 3 | 2018-09-15 | Duke (61) | 40 | Baylor (139) | 27 | Final | W | 13 |
| 4 | 2018-09-22 | North Carolina Central | 13 | Duke | 55 | Final | W | 42 |
| 5 | 2018-09-29 | Virginia Tech (76) | 31 | Duke (7) | 14 | Final | L | -17 |
| 6 | 2018-10-13 | Duke (23) | 28 | Georgia Tech (70) | 14 | Final | W | 14 |
| 7 | 2018-10-20 | Virginia (49) | 28 | Duke (18) | 14 | Final | L | -14 |
| 8 | 2018-10-27 | Duke (33) | 45 | Pittsburgh (77) | 54 | Final | L | -9 |
| 9 | 2018-11-03 | Duke (46) | 20 | Miami (36) | 12 | Final | W | 8 |
| 10 | 2018-11-10 | North Carolina (115) | 35 | Duke (38) | 42 | Final | W | 7 |
| 11 | 2018-11-17 | Duke (37) | 6 | Clemson (2) | 35 | Final | L | -29 |
| 12 | 2018-11-24 | Wake Forest (83) | 59 | Duke (34) | 7 | Final | L | -52 |
| 13 | 2018-12-27 | Temple (45) | 27 | Duke (47) | 56 | Final | W | 29 |