Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Furman (150) | 7 | Clemson (2) | 48 | Final | W | 41 |
| 2 | 2018-09-08 | Clemson (2) | 28 | Texas A&M (49) | 26 | Final | W | 2 |
| 3 | 2018-09-15 | Georgia Southern | 7 | Clemson | 38 | Final | W | 31 |
| 4 | 2018-09-22 | Clemson (2) | 49 | Georgia Tech (62) | 21 | Final | W | 28 |
| 5 | 2018-09-29 | Syracuse (13) | 23 | Clemson (11) | 27 | Final | W | 4 |
| 6 | 2018-10-06 | Clemson (6) | 63 | Wake Forest (64) | 3 | Final | W | 60 |
| 7 | 2018-10-20 | North Carolina State (12) | 7 | Clemson (3) | 41 | Final | W | 34 |
| 8 | 2018-10-27 | Clemson (2) | 59 | Florida State (72) | 10 | Final | W | 49 |
| 9 | 2018-11-03 | Louisville (116) | 16 | Clemson (1) | 77 | Final | W | 61 |
| 10 | 2018-11-10 | Clemson (2) | 27 | Boston College (30) | 7 | Final | W | 20 |
| 11 | 2018-11-17 | Duke (37) | 6 | Clemson (2) | 35 | Final | W | 29 |
| 12 | 2018-11-24 | South Carolina (26) | 35 | Clemson (2) | 56 | Final | W | 21 |
| 13 | 2018-12-01 | Clemson (2) | 42 | Pittsburgh (37) | 10 | Final | W | 32 |
| 14 | 2018-12-29 | Notre Dame (3) | 3 | Clemson (2) | 30 | Final | W | 27 |
| 15 | 2019-01-07 | Clemson (2) | 44 | Alabama (1) | 16 | Final | W | 28 |