Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Delaware State (239) | 10 | Buffalo (81) | 48 | Final | W | 38 |
| 2 | 2018-09-08 | Buffalo (81) | 36 | Temple (83) | 29 | Final | W | 7 |
| 3 | 2018-09-15 | Eastern Michigan | 28 | Buffalo | 35 | Final | W | 7 |
| 4 | 2018-09-22 | Buffalo (81) | 42 | Rutgers (99) | 13 | Final | W | 29 |
| 5 | 2018-09-29 | Army (41) | 42 | Buffalo (14) | 13 | Final | L | -29 |
| 6 | 2018-10-06 | Buffalo (51) | 34 | Central Michigan (123) | 24 | Final | W | 10 |
| 7 | 2018-10-13 | Akron (90) | 6 | Buffalo (46) | 24 | Final | W | 18 |
| 8 | 2018-10-20 | Buffalo (37) | 31 | Toledo (79) | 17 | Final | W | 14 |
| 9 | 2018-10-30 | Miami (OH) (91) | 42 | Buffalo (24) | 51 | Final | W | 9 |
| 10 | 2018-11-06 | Kent State (132) | 14 | Buffalo (23) | 48 | Final | W | 34 |
| 11 | 2018-11-14 | Buffalo (19) | 17 | Ohio (72) | 52 | Final | L | -35 |
| 12 | 2018-11-23 | Buffalo (39) | 44 | Bowling Green (125) | 14 | Final | W | 30 |
| 13 | 2018-11-30 | Northern Illinois (68) | 30 | Buffalo (34) | 29 | Final | L | -1 |
| 14 | 2018-12-22 | Buffalo (44) | 32 | Troy (46) | 42 | Final | L | -10 |