Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Tennessee State (202) | 29 | Eastern Washington (107) | 36 | Final | L | -7 |
| 2 | 2022-09-10 | Jackson State (126) | 16 | Tennessee State (202) | 3 | Final | L | -13 |
| 3 | 2022-09-17 | Tennessee State (240) | 6 | Middle Tennessee (71) | 49 | Final | L | -43 |
| 4 | 2022-10-01 | Lane | 28 | Tennessee State (258) | 27 | Final(OT) | L | -1 |
| 5 | 2022-10-08 | Bethune-Cookman (254) | 17 | Tennessee State (249) | 41 | Final | W | 24 |
| 6 | 2022-10-15 | Tennessee State (223) | 30 | Tennessee Tech (220) | 14 | Final | W | 16 |
| 7 | 2022-10-22 | Eastern Illinois (221) | 17 | Tennessee State (213) | 37 | Final | W | 20 |
| 8 | 2022-10-29 | Tennessee State (225) | 3 | Murray State (238) | 19 | Final | L | -16 |
| 9 | 2022-11-05 | Southeast Missouri State (146) | 42 | Tennessee State (232) | 0 | Final | L | -42 |
| 10 | 2022-11-12 | Tennessee-Martin (182) | 20 | Tennessee State (237) | 3 | Final | L | -17 |
| 11 | 2022-11-19 | Tennessee State (223) | 22 | Texas A&M-Commerce (220) | 14 | Final | W | 8 |