Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-29 | Western Illinois (223) | 3 | Illinois (17) | 52 | Final | L | -49 |
| 2 | 2025-09-05 | Western Illinois (223) | 7 | Northwestern (90) | 42 | Final | L | -35 |
| 3 | 2025-09-13 | Valparaiso (254) | 30 | Western Illinois (223) | 51 | Final | W | 21 |
| 4 | 2025-09-20 | Western Illinois (235) | 31 | Eastern Washington (227) | 52 | Final | L | -21 |
| 5 | 2025-09-27 | Eastern Illinois (211) | 31 | Western Illinois (251) | 23 | Final | L | -8 |
| 6 | 2025-10-04 | Western Illinois (249) | 20 | Tennessee Tech (143) | 66 | Final | L | -46 |
| 7 | 2025-10-11 | Western Illinois (249) | Tennessee-Martin (208) | Scheduled – 2:00 PM | – | – | ||
| 8 | 2025-10-18 | Charleston Southern (250) | 0 | Western Illinois (223) | 0 | Scheduled – 3:00 PM | – | – |
| 9 | 2025-10-25 | Western Illinois (223) | 0 | Tennessee State (171) | 0 | Scheduled – 1:30 PM | – | – |
| 10 | 2025-11-08 | Lindenwood (193) | 0 | Western Illinois (223) | 0 | Scheduled – 1:00 PM | – | – |
| 11 | 2025-11-15 | Southeast Missouri State (158) | 0 | Western Illinois (223) | 0 | Scheduled – 1:00 PM | – | – |
| 12 | 2025-11-22 | Western Illinois (223) | 0 | Gardner-Webb (201) | 0 | Scheduled – 1:30 PM | – | – |