Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | North Carolina A&T (257) | 21 | Tennessee State (171) | 24 | Final | W | 3 |
| 2 | 2025-09-06 | North Dakota State (69) | 59 | Tennessee State (171) | 3 | Final | L | -56 |
| 3 | 2025-09-13 | Alabama A&M (225) | 23 | Tennessee State (171) | 21 | Final | L | -2 |
| 4 | 2025-09-27 | Tennessee Tech (142) | 35 | Tennessee State (235) | 8 | Final | L | -27 |
| 5 | 2025-10-04 | Tennessee State (240) | 7 | Eastern Illinois (199) | 31 | Final | L | -24 |
| 6 | 2025-10-11 | Tennessee State (240) | Southeast Missouri State (228) | Scheduled – 3:00 PM | – | – | ||
| 7 | 2025-10-18 | Howard (243) | 0 | Tennessee State (171) | 0 | Scheduled – 4:30 PM | – | – |
| 8 | 2025-10-25 | Western Illinois (223) | 0 | Tennessee State (171) | 0 | Scheduled – 1:30 PM | – | – |
| 9 | 2025-11-01 | Lindenwood (193) | 0 | Tennessee State (171) | 0 | Scheduled – 3:30 PM | – | – |
| 10 | 2025-11-08 | Tennessee State (171) | 0 | Tennessee-Martin (137) | 0 | Scheduled – 1:00 PM | – | – |
| 11 | 2025-11-15 | Gardner-Webb (201) | 0 | Tennessee State (171) | 0 | Scheduled – 1:30 PM | – | – |
| 12 | 2025-11-22 | Tennessee State (171) | 0 | Charleston Southern (250) | 0 | Scheduled – 2:00 PM | – | – |