Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Thomas More | 3 | Southern Illinois (184) | 49 | Final | W | 46 |
| 2 | 2025-09-06 | Southern Illinois (184) | 17 | Purdue (133) | 34 | Final | L | -17 |
| 3 | 2025-09-13 | Southern Illinois (184) | 37 | Tennessee-Martin (137) | 10 | Final | W | 27 |
| 4 | 2025-09-20 | Southern Illinois (152) | 59 | Southeast Missouri State (206) | 31 | Final | W | 28 |
| 5 | 2025-10-04 | Indiana State (210) | 27 | Southern Illinois (146) | 55 | Final | W | 28 |
| 6 | 2025-10-11 | Southern Illinois (146) | North Dakota State (127) | Scheduled – 2:30 PM | – | – | ||
| 7 | 2025-10-18 | North Dakota (174) | 0 | Southern Illinois (184) | 0 | Scheduled – 2:00 PM | – | – |
| 8 | 2025-10-25 | Northern Iowa (206) | 0 | Southern Illinois (184) | 0 | Scheduled – 2:00 PM | – | – |
| 9 | 2025-11-01 | Southern Illinois (184) | 0 | Murray State (251) | 0 | Scheduled – 4:00 PM | – | – |
| 10 | 2025-11-08 | Southern Illinois (184) | 0 | Youngstown State (191) | 0 | Scheduled – 2:00 PM | – | – |
| 11 | 2025-11-15 | South Dakota (105) | 0 | Southern Illinois (184) | 0 | Scheduled – 12:00 PM | – | – |
| 12 | 2025-11-22 | Southern Illinois (184) | 0 | Illinois State (139) | 0 | Scheduled – 12:00 PM | – | – |