Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-23 | North Carolina Central (166) | 31 | Southern (199) | 14 | Final | L | -17 |
| 2 | 2025-08-30 | Southern (199) | 34 | Mississippi Valley State (261) | 29 | Final | W | 5 |
| 3 | 2025-09-06 | Alabama State (208) | 30 | Southern (199) | 7 | Final | L | -23 |
| 4 | 2025-09-13 | Southern (199) | 7 | Fresno State (100) | 56 | Final | L | -49 |
| 5 | 2025-09-27 | Jackson State (174) | 38 | Southern (247) | 13 | Final | L | -25 |
| 6 | 2025-10-11 | Southern (243) | 14 | Bethune-Cookman (209) | 45 | Final | L | -31 |
| 7 | 2025-10-18 | Prairie View A&M (172) | 24 | Southern (245) | 3 | Final | L | -21 |
| 8 | 2025-10-25 | Florida A&M (240) | 43 | Southern (256) | 35 | Final | L | -8 |
| 9 | 2025-11-01 | Southern (260) | 21 | Arkansas-Pine Bluff (255) | 40 | Final | L | -19 |
| 10 | 2025-11-08 | Southern (261) | 17 | Alcorn State (239) | 35 | Final | L | -18 |
| 11 | 2025-11-15 | Texas Southern (215) | 35 | Southern (259) | 30 | Final | L | -5 |
| 12 | 2025-11-29 | Grambling (208) | Southern (259) | Scheduled – 1:00 PM | – | – |