Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Southeastern Louisiana (155) | 0 | Louisiana Tech (125) | 24 | Final | L | -24 |
| 2 | 2025-09-06 | Southeastern Louisiana (155) | 45 | Murray State (251) | 24 | Final | W | 21 |
| 3 | 2025-09-13 | Mississippi Valley State (261) | 3 | Southeastern Louisiana (155) | 56 | Final | W | 53 |
| 4 | 2025-09-20 | Southeastern Louisiana (168) | 10 | LSU (10) | 56 | Final | L | -46 |
| 5 | 2025-09-27 | UTRGV (159) | 31 | Southeastern Louisiana (150) | 45 | Final | W | 14 |
| 6 | 2025-10-04 | Southeastern Louisiana (148) | 38 | McNeese (234) | 0 | Final | W | 38 |
| 7 | 2025-10-18 | Northwestern State (255) | 0 | Southeastern Louisiana (144) | 49 | Final | W | 49 |
| 8 | 2025-10-25 | Southeastern Louisiana (144) | 38 | Houston Christian (242) | 14 | Final | W | 24 |
| 9 | 2025-11-01 | East Texas A&M (229) | 14 | Southeastern Louisiana (140) | 59 | Final | W | 45 |
| 10 | 2025-11-08 | Southeastern Louisiana (151) | 12 | Lamar (148) | 14 | Final | L | -2 |
| 11 | 2025-11-15 | Southeastern Louisiana (150) | 10 | Incarnate Word (191) | 7 | Final | W | 3 |
| 12 | 2025-11-20 | Nicholls State (209) | 26 | Southeastern Louisiana (147) | 38 | Final | W | 12 |
| 13 | 2025-11-29 | Illinois State (159) | Southeastern Louisiana (147) | Scheduled – 12:00 PM | – | – |