Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Wofford (204) | 15 | South Carolina State (154) | 16 | Final | W | 1 |
| 2 | 2025-09-06 | South Carolina State (154) | 10 | South Carolina (13) | 38 | Final | L | -28 |
| 3 | 2025-09-13 | Bethune-Cookman (253) | 41 | South Carolina State (154) | 55 | Final | W | 14 |
| 4 | 2025-09-20 | South Carolina State (177) | 14 | South Florida (43) | 63 | Final | L | -49 |
| 5 | 2025-09-27 | South Carolina State (200) | 24 | Charleston Southern (219) | 31 | Final | L | -7 |
| 6 | 2025-10-04 | Savannah State | 6 | South Carolina State (202) | 49 | Final | W | 43 |
| 7 | 2025-10-11 | South Carolina State (191) | 22 | North Carolina A&T (255) | 16 | Final | W | 6 |
| 8 | 2025-10-25 | South Carolina State (180) | 51 | Norfolk State (263) | 20 | Final | W | 31 |
| 9 | 2025-11-01 | Morgan State (250) | 30 | South Carolina State (180) | 36 | Final | W | 6 |
| 10 | 2025-11-08 | Howard (252) | 12 | South Carolina State (178) | 42 | Final | W | 30 |
| 11 | 2025-11-14 | South Carolina State (175) | 34 | North Carolina Central (193) | 27 | Final | W | 7 |
| 12 | 2025-11-22 | South Carolina State (168) | 28 | Delaware State (192) | 17 | Final | W | 11 |