Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Prairie View A&M (236) | 22 | Texas Southern (230) | 21 | Final | W | 1 |
| 2 | 2025-09-06 | UTRGV | 27 | Prairie View A&M (236) | 21 | Final | L | -6 |
| 3 | 2025-09-13 | Prairie View A&M (236) | 17 | Rice (101) | 38 | Final | L | -21 |
| 4 | 2025-09-20 | Northwestern State (226) | 24 | Prairie View A&M (187) | 27 | Final | W | 3 |
| 5 | 2025-09-27 | Grambling (217) | 13 | Prairie View A&M (175) | 28 | Final | W | 15 |
| 6 | 2025-10-04 | Prairie View A&M (173) | 13 | Alcorn State (252) | 12 | Final | W | 1 |
| 7 | 2025-10-18 | Prairie View A&M (172) | 24 | Southern (245) | 3 | Final | W | 21 |
| 8 | 2025-10-25 | Lincoln (CA) | 0 | Prairie View A&M (168) | 38 | Final | W | 38 |
| 9 | 2025-11-01 | Alabama State (157) | 31 | Prairie View A&M (182) | 28 | Final | L | -3 |
| 10 | 2025-11-08 | Prairie View A&M (172) | 48 | Alabama A&M (236) | 5 | Final | W | 43 |
| 11 | 2025-11-15 | Arkansas-Pine Bluff (256) | 9 | Prairie View A&M (172) | 56 | Final | W | 47 |
| 12 | 2025-11-22 | Mississippi Valley State (264) | 6 | Prairie View A&M (171) | 59 | Final | W | 53 |