Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Ohio (42) | 31 | Rutgers (52) | 34 | Final | L | -3 |
| 2 | 2025-09-06 | West Virginia (67) | 0 | Ohio (42) | 0 | Scheduled – 4:00 PM | – | – |
| 3 | 2025-09-13 | Ohio (42) | 0 | Ohio State (1) | 0 | Scheduled – 7:00 PM | – | – |
| 4 | 2025-09-20 | Gardner-Webb (201) | 0 | Ohio (42) | 0 | Scheduled – 3:30 PM | – | – |
| 5 | 2025-09-27 | Bowling Green (86) | 0 | Ohio (42) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-04 | Ohio (42) | 0 | Ball State (130) | 0 | Scheduled – 12:00 PM | – | – |
| 7 | 2025-10-18 | Northern Illinois (71) | 0 | Ohio (42) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-25 | Ohio (42) | 0 | Eastern Michigan (117) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-04 | Miami (OH) (59) | 0 | Ohio (42) | 0 | Scheduled – 7:00 PM | – | – |
| 10 | 2025-11-11 | Ohio (42) | 0 | Western Michigan (104) | 0 | Scheduled – 7:30 PM | – | – |
| 11 | 2025-11-18 | Massachusetts (141) | 0 | Ohio (42) | 0 | Scheduled – 7:00 PM | – | – |
| 12 | 2025-11-28 | Ohio (42) | 0 | Buffalo (73) | 0 | Scheduled – 12:00 PM | – | – |