Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Northwestern (90) | 3 | Tulane (36) | 23 | Final | L | -20 |
| 2 | 2025-09-05 | Western Illinois (223) | 0 | Northwestern (90) | 0 | Scheduled – 6:30 PM | – | – |
| 3 | 2025-09-13 | Oregon (2) | 0 | Northwestern (90) | 0 | Scheduled – 11:00 AM | – | – |
| 4 | 2025-09-26 | UCLA (53) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-10-03 | Louisiana-Monroe (106) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-11 | Northwestern (90) | 0 | Penn State (5) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-17 | Purdue (133) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-24 | Northwestern (90) | 0 | Nebraska (47) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-07 | Northwestern (90) | 0 | USC (30) | 0 | Scheduled – 6:00 PM | – | – |
| 10 | 2025-11-14 | Michigan (18) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | Minnesota (32) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Northwestern (90) | 0 | Illinois (17) | 0 | Scheduled – TBD | – | – |