Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Murray State (251) | 17 | East Tennessee State (170) | 45 | Final | L | -28 |
| 2 | 2025-09-06 | Southeastern Louisiana (155) | 45 | Murray State (251) | 24 | Final | L | -21 |
| 3 | 2025-09-13 | Murray State (251) | 21 | Georgia State (116) | 37 | Final | L | -16 |
| 4 | 2025-09-20 | Murray State (246) | 10 | Jacksonville State (97) | 45 | Final | L | -35 |
| 5 | 2025-10-04 | Murray State (244) | 24 | South Dakota (180) | 49 | Final | L | -25 |
| 6 | 2025-10-11 | Illinois State (171) | Murray State (244) | Scheduled – 6:00 PM | – | – | ||
| 7 | 2025-10-18 | South Dakota State (92) | 0 | Murray State (251) | 0 | Scheduled – 6:00 PM | – | – |
| 8 | 2025-10-25 | Murray State (251) | 0 | Youngstown State (191) | 0 | Scheduled – 2:00 PM | – | – |
| 9 | 2025-11-01 | Southern Illinois (184) | 0 | Murray State (251) | 0 | Scheduled – 4:00 PM | – | – |
| 10 | 2025-11-08 | Murray State (251) | 0 | Northern Iowa (206) | 0 | Scheduled – 1:00 PM | – | – |
| 11 | 2025-11-15 | North Dakota (174) | 0 | Murray State (251) | 0 | Scheduled – 11:00 AM | – | – |
| 12 | 2025-11-22 | Murray State (251) | 0 | Indiana State (222) | 0 | Scheduled – 1:00 PM | – | – |