Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Missouri State (134) | 13 | USC (30) | 73 | Final | L | -60 |
| 2 | 2025-09-06 | Missouri State (134) | 21 | Marshall (37) | 20 | Final | W | 1 |
| 3 | 2025-09-13 | SMU (12) | 28 | Missouri State (134) | 10 | Final | L | -18 |
| 4 | 2025-09-20 | Tennessee-Martin (219) | 10 | Missouri State (111) | 42 | Final | W | 32 |
| 5 | 2025-09-27 | Western Kentucky (69) | 27 | Missouri State (113) | 22 | Final | L | -5 |
| 6 | 2025-10-08 | Missouri State (101) | 22 | Middle Tennessee (149) | 20 | Final | W | 2 |
| 7 | 2025-10-22 | Missouri State (134) | 0 | New Mexico State (149) | 0 | Scheduled – 7:00 PM | – | – |
| 8 | 2025-10-29 | Florida International (129) | 0 | Missouri State (134) | 0 | Scheduled – 7:00 PM | – | – |
| 9 | 2025-11-08 | Missouri State (134) | 0 | Liberty (95) | 0 | Scheduled – 1:00 PM | – | – |
| 10 | 2025-11-15 | UTEP (146) | 0 | Missouri State (134) | 0 | Scheduled – 2:00 PM | – | – |
| 11 | 2025-11-22 | Missouri State (134) | 0 | Kennesaw State (159) | 0 | Scheduled – 2:00 PM | – | – |
| 12 | 2025-11-29 | Louisiana Tech (125) | 0 | Missouri State (134) | 0 | Scheduled – 1:00 PM | – | – |