Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Southern (199) | 34 | Mississippi Valley State (261) | 29 | Final | L | -5 |
| 2 | 2025-09-06 | Mississippi Valley State (261) | 3 | Tarleton State (138) | 59 | Final | L | -56 |
| 3 | 2025-09-13 | Mississippi Valley State (261) | 3 | Southeastern Louisiana (155) | 56 | Final | L | -53 |
| 4 | 2025-09-27 | Texas Southern (226) | 23 | Mississippi Valley State (262) | 20 | Final | L | -3 |
| 5 | 2025-10-11 | Mississippi Valley State (262) | 25 | Alabama A&M (218) | 45 | Final | L | -20 |
| 6 | 2025-10-18 | Lincoln (CA) | 0 | Mississippi Valley State (256) | 49 | Final | W | 49 |
| 7 | 2025-10-25 | Mississippi Valley State (262) | 10 | Alcorn State (249) | 32 | Final | L | -22 |
| 8 | 2025-11-01 | Mississippi Valley State (262) | 34 | Bethune-Cookman (208) | 42 | Final | L | -8 |
| 9 | 2025-11-08 | Jackson State (166) | 42 | Mississippi Valley State (264) | 3 | Final | L | -39 |
| 10 | 2025-11-15 | Alabama State (158) | 41 | Mississippi Valley State (265) | 3 | Final | L | -38 |
| 11 | 2025-11-22 | Mississippi Valley State (264) | 6 | Prairie View A&M (171) | 59 | Final | L | -53 |
| 12 | 2025-11-29 | Florida A&M (224) | Mississippi Valley State (264) | Scheduled – 2:00 PM | – | – |