Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-29 | Western Michigan (104) | 6 | Michigan State (72) | 23 | Final | W | 17 |
| 2 | 2025-09-06 | Boston College (51) | 0 | Michigan State (72) | 0 | Scheduled – 7:30 PM | – | – |
| 3 | 2025-09-13 | Youngstown State (191) | 0 | Michigan State (72) | 0 | Scheduled – 3:30 PM | – | – |
| 4 | 2025-09-19 | Michigan State (72) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-10-03 | Michigan State (72) | 0 | Nebraska (47) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-11 | UCLA (53) | 0 | Michigan State (72) | 0 | Scheduled – 12:00 PM | – | – |
| 7 | 2025-10-18 | Michigan State (72) | 0 | Indiana (6) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-25 | Michigan (18) | 0 | Michigan State (72) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-10-31 | Michigan State (72) | 0 | Minnesota (32) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-15 | Penn State (5) | 0 | Michigan State (72) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | Michigan State (72) | 0 | Iowa (33) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Maryland (84) | 0 | Michigan State (72) | 0 | Scheduled – TBD | – | – |