Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Temple (126) | 42 | Massachusetts (141) | 10 | Final | L | -32 |
| 2 | 2025-09-06 | Bryant (248) | 0 | Massachusetts (141) | 0 | Scheduled – 3:30 PM | – | – |
| 3 | 2025-09-13 | Massachusetts (141) | 0 | Iowa (33) | 0 | Scheduled – 6:30 PM | – | – |
| 4 | 2025-09-26 | Massachusetts (141) | 0 | Missouri (23) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-10-04 | Western Michigan (104) | 0 | Massachusetts (141) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-11 | Massachusetts (141) | 0 | Kent State (196) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-18 | Buffalo (73) | 0 | Massachusetts (141) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-25 | Massachusetts (141) | 0 | Central Michigan (122) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-04 | Massachusetts (141) | 0 | Akron (113) | 0 | Scheduled – 7:00 PM | – | – |
| 10 | 2025-11-12 | Northern Illinois (71) | 0 | Massachusetts (141) | 0 | Scheduled – 7:00 PM | – | – |
| 11 | 2025-11-18 | Massachusetts (141) | 0 | Ohio (42) | 0 | Scheduled – 7:00 PM | – | – |
| 12 | 2025-11-25 | Bowling Green (86) | 0 | Massachusetts (141) | 0 | Scheduled – TBD | – | – |