Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Southeastern Louisiana (155) | 0 | Louisiana Tech (125) | 24 | Final | W | 24 |
| 2 | 2025-09-06 | Louisiana Tech (125) | 7 | LSU (19) | 23 | Final | L | -16 |
| 3 | 2025-09-13 | New Mexico State (149) | 14 | Louisiana Tech (125) | 49 | Final | W | 35 |
| 4 | 2025-09-20 | Southern Miss (73) | 20 | Louisiana Tech (40) | 30 | Final | W | 10 |
| 5 | 2025-09-27 | Louisiana Tech (44) | 30 | UTEP (118) | 11 | Final | W | 19 |
| 6 | 2025-10-09 | Louisiana Tech (58) | 7 | Kennesaw State (62) | 35 | Final | L | -28 |
| 7 | 2025-10-21 | Western Kentucky (84) | 28 | Louisiana Tech (60) | 27 | Final/OT | L | -1 |
| 8 | 2025-10-31 | Sam Houston State (65) | 0 | Louisiana Tech (125) | 0 | Scheduled – 7:00 PM | – | – |
| 9 | 2025-11-08 | Louisiana Tech (125) | 0 | Delaware (140) | 0 | Scheduled – 3:00 PM | – | – |
| 10 | 2025-11-15 | Louisiana Tech (125) | 0 | Washington State (70) | 0 | Scheduled – 7:00 PM | – | – |
| 11 | 2025-11-22 | Liberty (95) | 0 | Louisiana Tech (125) | 0 | Scheduled – 2:00 PM | – | – |
| 12 | 2025-11-29 | Louisiana Tech (125) | 0 | Missouri State (134) | 0 | Scheduled – 1:00 PM | – | – |