Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-23 | Iowa State (21) | 24 | Kansas State (31) | 21 | Final | W | 3 |
| 2 | 2025-08-30 | South Dakota (105) | 7 | Iowa State (21) | 55 | Final | W | 48 |
| 3 | 2025-09-06 | Iowa (33) | 0 | Iowa State (21) | 0 | Scheduled – 11:00 AM | – | – |
| 4 | 2025-09-13 | Iowa State (21) | 0 | Arkansas State (89) | 0 | Scheduled – 3:00 PM | – | – |
| 5 | 2025-09-26 | Arizona (102) | 0 | Iowa State (21) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-04 | Iowa State (21) | 0 | Cincinnati (66) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-10 | Iowa State (21) | 0 | Colorado (35) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-24 | BYU (14) | 0 | Iowa State (21) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-10-31 | Arizona State (16) | 0 | Iowa State (21) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-07 | Iowa State (21) | 0 | TCU (39) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | Kansas (50) | 0 | Iowa State (21) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Iowa State (21) | 0 | Oklahoma State (110) | 0 | Scheduled – TBD | – | – |