Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Langston | 7 | Grambling (231) | 55 | Final | W | 48 |
| 2 | 2025-09-06 | Grambling (231) | 0 | Ohio State (1) | 70 | Final | L | -70 |
| 3 | 2025-09-13 | Kentucky State | 31 | Grambling (231) | 37 | Final/OT | W | 6 |
| 4 | 2025-09-20 | East Texas A&M (239) | 28 | Grambling (194) | 31 | Final | W | 3 |
| 5 | 2025-09-27 | Grambling (217) | 13 | Prairie View A&M (175) | 28 | Final | L | -15 |
| 6 | 2025-10-11 | Texas Southern (206) | Grambling (212) | Scheduled – 6:00 PM | – | – | ||
| 7 | 2025-10-18 | Grambling (231) | 0 | Arkansas-Pine Bluff (252) | 0 | Scheduled – 2:00 PM | – | – |
| 8 | 2025-10-25 | Jackson State (136) | 0 | Grambling (231) | 0 | Scheduled – 3:00 PM | – | – |
| 9 | 2025-10-31 | Alabama A&M (225) | 0 | Grambling (231) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-07 | Bethune-Cookman (253) | 0 | Grambling (231) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-15 | Grambling (231) | 0 | Alcorn State (215) | 0 | Scheduled – 2:00 PM | – | – |
| 12 | 2025-11-29 | Grambling (231) | 0 | Southern (199) | 0 | Scheduled – 1:00 PM | – | – |