Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Langston | 7 | Grambling (231) | 55 | Final | W | 48 |
| 2 | 2025-09-06 | Grambling (231) | 0 | Ohio State (1) | 70 | Final | L | -70 |
| 3 | 2025-09-13 | Kentucky State | 31 | Grambling (231) | 37 | Final/OT | W | 6 |
| 4 | 2025-09-20 | East Texas A&M (239) | 28 | Grambling (194) | 31 | Final | W | 3 |
| 5 | 2025-09-27 | Grambling (217) | 13 | Prairie View A&M (175) | 28 | Final | L | -15 |
| 6 | 2025-10-11 | Texas Southern (198) | 21 | Grambling (231) | 20 | Final | L | -1 |
| 7 | 2025-10-18 | Grambling (225) | 20 | Arkansas-Pine Bluff (261) | 16 | Final | W | 4 |
| 8 | 2025-10-25 | Jackson State (170) | 24 | Grambling (199) | 26 | Final | W | 2 |
| 9 | 2025-11-01 | Alabama A&M (231) | 10 | Grambling (197) | 13 | Final | W | 3 |
| 10 | 2025-11-08 | Bethune-Cookman (216) | 23 | Grambling (188) | 31 | Final | W | 8 |
| 11 | 2025-11-15 | Grambling (206) | 16 | Alcorn State (226) | 27 | Final | L | -11 |
| 12 | 2025-11-29 | Grambling (208) | Southern (259) | Scheduled – 1:00 PM | – | – |