Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Murray State (251) | 17 | East Tennessee State (170) | 45 | Final | W | 28 |
| 2 | 2025-09-06 | East Tennessee State (170) | 17 | Tennessee (9) | 72 | Final | L | -55 |
| 3 | 2025-09-13 | East Tennessee State (170) | 31 | West Georgia (221) | 35 | Final | L | -4 |
| 4 | 2025-09-20 | Elon (188) | 16 | East Tennessee State (165) | 26 | Final | W | 10 |
| 5 | 2025-09-27 | Mercer (153) | 38 | East Tennessee State (186) | 34 | Final | L | -4 |
| 6 | 2025-10-04 | East Tennessee State (191) | 22 | Furman (153) | 31 | Final | L | -9 |
| 7 | 2025-10-11 | Virginia Military (245) | East Tennessee State (191) | Scheduled – 3:30 PM | – | – | ||
| 8 | 2025-10-18 | East Tennessee State (170) | 0 | Chattanooga (172) | 0 | Scheduled – 1:30 PM | – | – |
| 9 | 2025-10-25 | Wofford (204) | 0 | East Tennessee State (170) | 0 | Scheduled – 3:30 PM | – | – |
| 10 | 2025-11-08 | East Tennessee State (170) | 0 | Samford (198) | 0 | Scheduled – 2:30 PM | – | – |
| 11 | 2025-11-15 | East Tennessee State (170) | 0 | Western Carolina (175) | 0 | Scheduled – 12:00 PM | – | – |
| 12 | 2025-11-22 | The Citadel (216) | 0 | East Tennessee State (170) | 0 | Scheduled – 1:00 PM | – | – |