Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | LSU (19) | 17 | Clemson (22) | 10 | Final | L | -7 |
| 2 | 2025-09-06 | Troy (112) | 0 | Clemson (22) | 0 | Scheduled – 3:30 PM | – | – |
| 3 | 2025-09-13 | Clemson (22) | 0 | Georgia Tech (43) | 0 | Scheduled – 12:00 PM | – | – |
| 4 | 2025-09-20 | Syracuse (27) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-10-04 | Clemson (22) | 0 | North Carolina (79) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-11 | Clemson (22) | 0 | Boston College (51) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-18 | SMU (12) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-11-01 | Duke (44) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-08 | Florida State (111) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-14 | Clemson (22) | 0 | Louisville (20) | 0 | Scheduled – 8:00 PM | – | – |
| 11 | 2025-11-22 | Furman (241) | 0 | Clemson (22) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Clemson (22) | 0 | South Carolina (13) | 0 | Scheduled – 12:00 PM | – | – |