Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Charleston Southern (250) | 3 | Vanderbilt (40) | 45 | Final | L | -42 |
| 2 | 2025-09-06 | Charleston Southern (250) | 0 | Coastal Carolina (99) | 13 | Final | L | -13 |
| 3 | 2025-09-13 | Lindenwood (193) | 35 | Charleston Southern (250) | 28 | Final | L | -7 |
| 4 | 2025-09-20 | Charleston Southern (254) | 7 | William & Mary (193) | 34 | Final | L | -27 |
| 5 | 2025-09-27 | South Carolina State (200) | 24 | Charleston Southern (219) | 31 | Final | W | 7 |
| 6 | 2025-10-04 | Charleston Southern (225) | 27 | Gardner-Webb (158) | 30 | Final | L | -3 |
| 7 | 2025-10-11 | Tennessee Tech (143) | Charleston Southern (225) | Scheduled – 4:00 PM | – | – | ||
| 8 | 2025-10-18 | Charleston Southern (250) | 0 | Western Illinois (223) | 0 | Scheduled – 3:00 PM | – | – |
| 9 | 2025-10-25 | Eastern Illinois (226) | 0 | Charleston Southern (250) | 0 | Scheduled – 2:00 PM | – | – |
| 10 | 2025-11-01 | Charleston Southern (250) | 0 | Southeast Missouri State (158) | 0 | Scheduled – 1:00 PM | – | – |
| 11 | 2025-11-15 | Charleston Southern (250) | 0 | Tennessee-Martin (137) | 0 | Scheduled – 1:00 PM | – | – |
| 12 | 2025-11-22 | Tennessee State (171) | 0 | Charleston Southern (250) | 0 | Scheduled – 2:00 PM | – | – |