Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-01 | UAB | 31 | Jacksonville State | 0 | Final | W | 31 |
| 2 | 2021-09-11 | UAB | 7 | Georgia | 56 | Final | L | -49 |
| 3 | 2021-09-18 | UAB | 40 | North Texas | 6 | Final | W | 34 |
| 4 | 2021-09-25 | UAB | 28 | Tulane | 21 | Final | W | 7 |
| 5 | 2021-10-02 | Liberty | 36 | UAB | 12 | Final | L | -24 |
| 6 | 2021-10-09 | Florida Atlantic | 14 | UAB | 31 | Final | W | 17 |
| 7 | 2021-10-16 | UAB | 34 | Southern Miss | 0 | Final | W | 34 |
| 8 | 2021-10-23 | Rice | 30 | UAB | 24 | Final | L | -6 |
| 9 | 2021-11-06 | Louisiana Tech | 38 | UAB | 52 | Final | W | 14 |
| 10 | 2021-11-13 | UAB | 21 | Marshall | 14 | Final | W | 7 |
| 11 | 2021-11-20 | UAB | 31 | UTSA | 34 | Final | L | -3 |
| 12 | 2021-11-26 | UTEP (89) | 25 | UAB (56) | 42 | Final | W | 17 |
| 13 | 2021-12-18 | UAB (46) | 31 | BYU (25) | 28 | Final | W | 3 |