Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Colgate | 0 | Boston College | 51 | Final | L | -51 |
| 2 | 2021-09-11 | Stony Brook | 24 | Colgate | 3 | Final | L | -21 |
| 3 | 2021-09-18 | William & Mary | 27 | Colgate | 7 | Final | L | -20 |
| 4 | 2021-09-25 | Lehigh | 3 | Colgate | 30 | Final | W | 27 |
| 5 | 2021-10-02 | Colgate | 28 | Georgetown | 21 | Final | W | 7 |
| 6 | 2021-10-09 | Colgate | 10 | Brown | 31 | Final | L | -21 |
| 7 | 2021-10-15 | Colgate | 20 | Cornell | 34 | Final | L | -14 |
| 8 | 2021-10-23 | Colgate | 10 | Holy Cross | 42 | Final | L | -32 |
| 9 | 2021-10-30 | Bucknell | 10 | Colgate | 33 | Final | W | 23 |
| 10 | 2021-11-13 | Colgate | 20 | Lafayette | 13 | Final | W | 7 |
| 11 | 2021-11-20 | Fordham | 31 | Colgate | 45 | Final | W | 14 |