Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Missouri State (134) | 13 | USC (30) | 73 | Final | W | 60 |
| 2 | 2025-09-06 | Georgia Southern (62) | 20 | USC (30) | 59 | Final | W | 39 |
| 3 | 2025-09-13 | USC (30) | 0 | Purdue (133) | 0 | Scheduled – 3:30 PM | – | – |
| 4 | 2025-09-19 | Michigan State (72) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-09-26 | USC (30) | 0 | Illinois (17) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-10 | Michigan (18) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-18 | USC (30) | 0 | Notre Dame (3) | 0 | Scheduled – 7:30 PM | – | – |
| 8 | 2025-10-31 | USC (30) | 0 | Nebraska (47) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-07 | Northwestern (90) | 0 | USC (30) | 0 | Scheduled – 6:00 PM | – | – |
| 10 | 2025-11-14 | Iowa (33) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-21 | USC (30) | 0 | Oregon (2) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | UCLA (53) | 0 | USC (30) | 0 | Scheduled – TBD | – | – |