Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Georgia State (116) | 7 | Ole Miss (8) | 63 | Final | W | 56 |
| 2 | 2025-09-06 | Ole Miss (8) | 30 | Kentucky (63) | 23 | Final | W | 7 |
| 3 | 2025-09-13 | Arkansas (46) | 35 | Ole Miss (8) | 41 | Final | W | 6 |
| 4 | 2025-09-20 | Tulane (41) | 10 | Ole Miss (2) | 45 | Final | W | 35 |
| 5 | 2025-09-27 | LSU (22) | 19 | Ole Miss (2) | 24 | Final | W | 5 |
| 6 | 2025-10-11 | Washington State (66) | 21 | Ole Miss (6) | 24 | Final | W | 3 |
| 7 | 2025-10-18 | Ole Miss (10) | 35 | Georgia (9) | 43 | Final | L | -8 |
| 8 | 2025-10-25 | Ole Miss (8) | 34 | Oklahoma (20) | 26 | Final | W | 8 |
| 9 | 2025-11-01 | South Carolina (67) | 14 | Ole Miss (6) | 30 | Final | W | 16 |
| 10 | 2025-11-08 | The Citadel (223) | 0 | Ole Miss (7) | 49 | Final | W | 49 |
| 11 | 2025-11-15 | Florida (58) | Ole Miss (7) | Scheduled – 6:00 PM | – | – | ||
| 12 | 2025-11-28 | Ole Miss (8) | 0 | Mississippi State (108) | 0 | Scheduled – 11:00 AM | – | – |