Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Old Dominion (81) | 14 | Indiana (6) | 27 | Final | L | -13 |
| 2 | 2025-09-06 | North Carolina Central (166) | 6 | Old Dominion (81) | 54 | Final | W | 48 |
| 3 | 2025-09-13 | Old Dominion (81) | 45 | Virginia Tech (45) | 26 | Final | W | 19 |
| 4 | 2025-09-27 | Liberty (130) | 7 | Old Dominion (40) | 21 | Final | W | 14 |
| 5 | 2025-10-04 | Coastal Carolina (108) | 7 | Old Dominion (34) | 47 | Final | W | 40 |
| 6 | 2025-10-11 | Old Dominion (53) | 24 | Marshall (96) | 48 | Final | L | -24 |
| 7 | 2025-10-18 | Old Dominion (59) | 27 | James Madison (32) | 63 | Final | L | -36 |
| 8 | 2025-10-25 | Appalachian State (110) | 21 | Old Dominion (57) | 24 | Final | W | 3 |
| 9 | 2025-11-01 | Old Dominion (49) | 31 | Louisiana-Monroe (122) | 6 | Final | W | 25 |
| 10 | 2025-11-13 | Troy (79) | 0 | Old Dominion (50) | 33 | Final | W | 33 |
| 11 | 2025-11-22 | Old Dominion (81) | 0 | Georgia Southern (62) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Georgia State (116) | 0 | Old Dominion (81) | 0 | Scheduled – TBD | – | – |