Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Texas (4) | 7 | Ohio State (1) | 14 | Final | W | 7 |
| 2 | 2025-09-06 | Grambling (231) | 0 | Ohio State (1) | 70 | Final | W | 70 |
| 3 | 2025-09-13 | Ohio (42) | 9 | Ohio State (1) | 37 | Final | W | 28 |
| 4 | 2025-09-27 | Ohio State (3) | 24 | Washington (35) | 6 | Final | W | 18 |
| 5 | 2025-10-04 | Minnesota (53) | 3 | Ohio State (4) | 42 | Final | W | 39 |
| 6 | 2025-10-11 | Ohio State (2) | 34 | Illinois (13) | 16 | Final | W | 18 |
| 7 | 2025-10-18 | Ohio State (2) | 34 | Wisconsin (94) | 0 | Final | W | 34 |
| 8 | 2025-11-01 | Penn State (80) | 14 | Ohio State (2) | 38 | Final | W | 24 |
| 9 | 2025-11-08 | Ohio State (2) | 34 | Purdue (107) | 10 | Final | W | 24 |
| 10 | 2025-11-15 | UCLA (81) | Ohio State (2) | Scheduled – 7:30 PM | – | – | ||
| 11 | 2025-11-22 | Rutgers (52) | 0 | Ohio State (1) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Ohio State (1) | 0 | Michigan (18) | 0 | Scheduled – 12:00 PM | – | – |