Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Texas (4) | 7 | Ohio State (1) | 14 | Final | W | 7 |
| 2 | 2025-09-06 | Grambling (231) | 0 | Ohio State (1) | 70 | Final | W | 70 |
| 3 | 2025-09-13 | Ohio (42) | 0 | Ohio State (1) | 0 | Scheduled – 7:00 PM | – | – |
| 4 | 2025-09-26 | Ohio State (1) | 0 | Washington (49) | 0 | Scheduled – TBD | – | – |
| 5 | 2025-10-04 | Minnesota (32) | 0 | Ohio State (1) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-10 | Ohio State (1) | 0 | Illinois (17) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-17 | Ohio State (1) | 0 | Wisconsin (64) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-11-01 | Penn State (5) | 0 | Ohio State (1) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-08 | Ohio State (1) | 0 | Purdue (133) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-15 | UCLA (53) | 0 | Ohio State (1) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-22 | Rutgers (52) | 0 | Ohio State (1) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Ohio State (1) | 0 | Michigan (18) | 0 | Scheduled – 12:00 PM | – | – |