Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Ohio (42) | 31 | Rutgers (52) | 34 | Final | L | -3 |
| 2 | 2025-09-06 | West Virginia (67) | 10 | Ohio (42) | 17 | Final | W | 7 |
| 3 | 2025-09-13 | Ohio (42) | 9 | Ohio State (1) | 37 | Final | L | -28 |
| 4 | 2025-09-20 | Gardner-Webb (169) | 35 | Ohio (79) | 52 | Final | W | 17 |
| 5 | 2025-09-27 | Bowling Green (102) | 20 | Ohio (70) | 35 | Final | W | 15 |
| 6 | 2025-10-04 | Ohio (88) | 14 | Ball State (109) | 20 | Final | L | -6 |
| 7 | 2025-10-18 | Northern Illinois (143) | 21 | Ohio (85) | 48 | Final | W | 27 |
| 8 | 2025-10-25 | Ohio (80) | 28 | Eastern Michigan (142) | 21 | Final | W | 7 |
| 9 | 2025-11-04 | Miami (OH) (93) | 20 | Ohio (69) | 24 | Final | W | 4 |
| 10 | 2025-11-11 | Ohio (69) | 13 | Western Michigan (89) | 17 | Final | L | -4 |
| 11 | 2025-11-18 | Massachusetts (141) | 0 | Ohio (42) | 0 | Scheduled – 7:00 PM | – | – |
| 12 | 2025-11-28 | Ohio (42) | 0 | Buffalo (73) | 0 | Scheduled – 12:00 PM | – | – |