Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Northwestern (90) | 3 | Tulane (36) | 23 | Final | L | -20 |
| 2 | 2025-09-05 | Western Illinois (223) | 7 | Northwestern (90) | 42 | Final | W | 35 |
| 3 | 2025-09-13 | Oregon (2) | 34 | Northwestern (90) | 14 | Final | L | -20 |
| 4 | 2025-09-27 | UCLA (126) | 14 | Northwestern (84) | 17 | Final | W | 3 |
| 5 | 2025-10-04 | Louisiana-Monroe (90) | 7 | Northwestern (58) | 42 | Final | W | 35 |
| 6 | 2025-10-11 | Northwestern (48) | 22 | Penn State (80) | 21 | Final | W | 1 |
| 7 | 2025-10-18 | Purdue (95) | 0 | Northwestern (42) | 19 | Final | W | 19 |
| 8 | 2025-10-25 | Northwestern (51) | 21 | Nebraska (31) | 28 | Final | L | -7 |
| 9 | 2025-11-07 | Northwestern (55) | 17 | USC (12) | 38 | Final | L | -21 |
| 10 | 2025-11-15 | Michigan (18) | Northwestern (55) | Scheduled – 11:00 AM | – | – | ||
| 11 | 2025-11-21 | Minnesota (32) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Northwestern (90) | 0 | Illinois (17) | 0 | Scheduled – TBD | – | – |