Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Mississippi State (108) | 34 | Southern Miss (157) | 17 | Final | W | 17 |
| 2 | 2025-09-06 | Arizona State (16) | 20 | Mississippi State (108) | 24 | Final | W | 4 |
| 3 | 2025-09-13 | Alcorn State (215) | 0 | Mississippi State (108) | 63 | Final | W | 63 |
| 4 | 2025-09-20 | Northern Illinois (105) | 10 | Mississippi State (6) | 38 | Final | W | 28 |
| 5 | 2025-09-27 | Tennessee (21) | 41 | Mississippi State (23) | 34 | Final/OT | L | -7 |
| 6 | 2025-10-04 | Mississippi State (37) | 9 | Texas A&M (5) | 31 | Final | L | -22 |
| 7 | 2025-10-18 | Mississippi State (45) | 21 | Florida (46) | 23 | Final | L | -2 |
| 8 | 2025-10-25 | Texas (27) | 45 | Mississippi State (49) | 38 | Final/OT | L | -7 |
| 9 | 2025-11-01 | Mississippi State (47) | 38 | Arkansas (90) | 35 | Final | W | 3 |
| 10 | 2025-11-08 | Georgia (6) | 41 | Mississippi State (47) | 21 | Final | L | -20 |
| 11 | 2025-11-15 | Mississippi State (47) | Missouri (29) | Scheduled – 6:45 PM | – | – | ||
| 12 | 2025-11-28 | Ole Miss (8) | 0 | Mississippi State (108) | 0 | Scheduled – 11:00 AM | – | – |