Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Eastern Kentucky (162) | 17 | Louisville (20) | 51 | Final | W | 34 |
| 2 | 2025-09-05 | James Madison (56) | 14 | Louisville (20) | 28 | Final | W | 14 |
| 3 | 2025-09-20 | Bowling Green (99) | 17 | Louisville (27) | 40 | Final | W | 23 |
| 4 | 2025-09-27 | Louisville (19) | 34 | Pittsburgh (77) | 27 | Final | W | 7 |
| 5 | 2025-10-04 | Virginia (22) | 30 | Louisville (32) | 27 | Final/OT | L | -3 |
| 6 | 2025-10-17 | Louisville (13) | 24 | Miami (6) | 21 | Final | W | 3 |
| 7 | 2025-10-25 | Boston College (136) | 24 | Louisville (14) | 38 | Final | W | 14 |
| 8 | 2025-11-01 | Louisville (12) | 28 | Virginia Tech (87) | 16 | Final | W | 12 |
| 9 | 2025-11-08 | California (76) | 29 | Louisville (13) | 26 | Final/OT | L | -3 |
| 10 | 2025-11-14 | Clemson (63) | 3 | Louisville (13) | 3 | 13:34 – 2nd Quarter | L | -0 |
| 11 | 2025-11-21 | Louisville (20) | 0 | SMU (12) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-29 | Kentucky (63) | 0 | Louisville (20) | 0 | Scheduled – TBD | – | – |