Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Rice (101) | 14 | Louisiana (54) | 12 | Final | L | -2 |
| 2 | 2025-09-06 | McNeese (185) | 10 | Louisiana (54) | 34 | Final | W | 24 |
| 3 | 2025-09-13 | Louisiana (54) | 10 | Missouri (23) | 52 | Final | L | -42 |
| 4 | 2025-09-20 | Louisiana (130) | 31 | Eastern Michigan (135) | 34 | Final | L | -3 |
| 5 | 2025-09-27 | Marshall (124) | 51 | Louisiana (139) | 54 | Final/2OT | W | 3 |
| 6 | 2025-10-11 | Louisiana (123) | 14 | James Madison (47) | 24 | Final | L | -10 |
| 7 | 2025-10-18 | Southern Miss (62) | 22 | Louisiana (125) | 10 | Final | L | -12 |
| 8 | 2025-10-25 | Louisiana (126) | 23 | Troy (65) | 35 | Final | L | -12 |
| 9 | 2025-11-01 | Louisiana (123) | 31 | South Alabama (131) | 22 | Final | W | 9 |
| 10 | 2025-11-08 | Texas State (114) | 39 | Louisiana (113) | 42 | Final | W | 3 |
| 11 | 2025-11-20 | Louisiana (54) | 0 | Arkansas State (89) | 0 | Scheduled – 6:30 PM | – | – |
| 12 | 2025-11-28 | Louisiana-Monroe (106) | 0 | Louisiana (54) | 0 | Scheduled – TBD | – | – |